Will 5G Impact Our Cell Phone Plans (or Our Health?! Then a comparison will be made between the experiments carried out in the laboratory and how the production of aspirin is carried out in industry. stream How about make it original at only $13.9/page? Sulfuric acid increased the rate of reaction the most by reducing the energy of the reaction’s transition state(s) and thus lowering the reaction’s activation energy. salicylic acid (salicylate ion) to give a purple solution. Sorry, but copying text is forbidden on this website. Very small test tube Reaction Equations: Salicylic acid + acetic anhydride –> acetylsalicylic acid + acetic acid (C7H6O3) + (C4H6O3) –> (C9H8O4) + (C2H4O2) References: ———————– [i] [ii] Chemicalland: Lifestyle. Measure the mass of a separate beaker in which you are going to use later in the experiment. SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Quality control departments. ? The first major differences are[iv]: ? Size of the apparatus ? These two qualitative tests could be improved by making them quantitative tests. The general mechanism for catalysation by a base, like the acetate ion or pyridine, is shown in Figure 2. Therefore the balance did not have a very good precision and would give a percentage error in the reading. Balance ? Some test tubes developed into a gummy polymer of salicylic acid, likely because they were heated for too long. It is used to treat pain, reduce fever, and to decrease the aggregation of platelets, such as to decrease blood clotting. The melting point of the Acetylsalicylic acid (Aspirin) was found to be 121°C according to the experiment carried out. 8.1 Use of apparatus and techniques. Preparing Aspirin is a classic lab synthesis performed in university and school. The textbook “Handbook of Chemistry and Physics” showed the melting point of aspirin had a value of 135°C. The reactant that runs out first is called the limiting reagent. Additionally, the exothermic reaction of salicylic acid acetylation is not the sole process influencing the temperature, as the method assumes. your own paper. As you see it starting to melt makes a note of the temperature. Reagent A – Weigh 1.00 g of the aspirin product into a 50 mL beaker. Procedure and Experimental Technique: Method of Production of Aspirin: ? Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from, To prepare aspirin, salicylic acid is reacted with an excess of acetic, anhydride. about. The produced (PhO)2Fe(II) species is a dark purple color, the presence of which indicates the presence of phenol functional groups in an unknown compound. Balance: The balance used to calculate the mass of the wet and dry product along with the beaker was considerably outdated. A small melting point range close to the standard of acetylsalicylic acid would suggest a high purity sample, meaning the recrystallization process was effective. htm [Accessed 05 MAR 2009] [iv] How products are made: Volume 1. Unknown compound D was determined to be pure salicylic acid because it had, qualitatively, the darkest, strongest purple color, as can be seen from Table 3. The report progresses further giving details to the procedure carried out and the experimental technique that has been developed to show how aspirin is produced. Fume cupboards were also used to ensure any dangerous vapour was not inhaled and also to keep the apprentice at a safe distance in case any vigorous reactions took place. This is why pyridine increases the rate of reaction more so than the acetate ion. ? ? Student worksheets at higher level. The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form ofsalicylic acid (salicylate ion) to give a purple solution. Due to the time factor it was unable to make this judgment. 3623 = 65. Therefore the difference in yield from the actual yield produced compared to the theoretical yield will give a direct indication on how temperature changes affects the aspirin produced. 01 g of aspirin per gram of water. html [Accessed 05 MAR 2009] Appendices: Appendix A- word processer used The document is word processed using Microsoft ® Word 2003 and is saved in the compatibility mode for word 2007, Synthesis of Acetyl Salicylic Acid (Aspirin). 3623 mol + 0. 0. For example the reflux used in the experiment has some sort of residue contained inside it. A small amount of a strong acid is used as a catalyst that speeds up the reaction. 3623 mol + 0. This will be the wet weight. Practical activity group. The aspirin product is not very soluble in water so the aspirin product willprecipitate when water is added. Assess learning with questions exploring the topic of burning hydrocarbons. endobj As a result it had to be assumed they were correct. Measure out 50g of salicylic acid with care. However when 70°C was reached and the heater was turned off, it was observed that the temperature on the thermometer had risen around 10°C more after this point. Therefore you should get a temperature range of the aspirin Hazard and Risk Analysis: Included with the report is the MSDS data sheet. Gently heat the Quick-fit flask mixture for 30 minutes at 70 degrees. Pyridine also activates the electrophile by reacting with acetic anhydride to form the N-acyliminium ion, as seen in Figure 3.

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